Structure function analysis of Leishmania sirtuin: An ensemble of In silico and biochemical studies

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Rameshwar U Kadam (Autor) Outra; Joana Tavares (Autor) FFUP; Kiran, VM (Autor) Outra; Anabela Cordeiro (Autor) FFUP; Ali Ouaissi (Autor) Outra; Nilanjan Roy (Autor) Outra

Revista

Título: Chemical Biology and Drug Design

Vol. 71

Páginas: 501-506

ISSN: 1747-0277

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 13 Citações

ISI Web of Science

Scopus - 16 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-003-ZJN

DOI: 10.1111/j.1747-0285.2008.00652.x

Resumo (PT): Novel anti-leishmanial target LmSir2 has few subtle but prudent structural differences in ligand binding and catalytic domain as compared to its human counterpart. In silico screening and validation followed by in vitro deacetylation and cell killing assays described herein give a proof of concept for development of strategies exploiting such minor differences for screening libraries of small molecules to identify selective inhibitors. <br> <br> Key words: leishmaniasis, nicotinamide and virtual screening, Sir2 <br> <a target="_blank" href="http://web.ebscohost.com/ehost/detail?vid=3&hid=106&sid=7436bf0e-ef17-48be-9c94-3f343d40468b%40sessionmgr109&bdata=JnNpdGU9ZWhvc3QtbGl2ZSZzY29wZT1zaXRl#db=a2h&AN=31573659#db=a2h&AN=31573659#db=a2h&AN=31573659"> Texto integral</a> <br> <br>

Abstract (EN): Novel anti-leishmanial target LmSir2 has few subtle but prudent structural differences in ligand binding and catalytic domain as compared to its human counterpart. In silico screening and validation followed by in vitro deacetylation and cell killing assays described herein give a proof of concept for development of strategies exploiting such minor differences for screening libraries of small molecules to identify selective inhibitors.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6