Pharmacogenetic Approaches in Personalized Medicine for Postoperative Pain Management

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2024

Autores

do Couto, MLF (Autor) Outra; Fonseca, S (Autor) Outra; Daniel Pozza (Autor) FMUP

Revista

Título: Biomedicines

Vol. 12

Página Final: 729

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-010-CHW

DOI: 10.3390/biomedicines12040729

Abstract (EN): Despite technical and pharmacological advancements in recent years, including optimized therapies and personalized medicine, postoperative pain management remains challenging and sometimes undertreated. This review aims to summarize and update how genotype-guided therapeutics within personalized medicine can enhance postoperative pain management. Several studies in the area have demonstrated that genotype-guided therapy has the ability to lower opioid consumption and improve postoperative pain. Gene mutations, primarily OPRM1, CYP2D6, CYP2C9, COMT and ABCB1, have been shown to exert nuanced influences on analgesic response and related pharmacological outcomes. This review underscores the integration of pharmacogenetic-guided personalized medicine into perioperative care, particularly when there is uncertainty regarding opioid prescriptions. This approach leads to superior outcomes in terms of postoperative pain relief and reduced morbidity for numerous patients.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 20