Physicochemical, pharmacokinetic, and pharmacodynamic characterization of isradipine tablets for controlled release

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Venkatesh, DN (Autor) Outra; Meyyanathan, SN (Autor) Outra; Shanmugam, R (Autor) Outra; Kamatham, SS (Autor) Outra; Campos, JR (Autor) Outra; Dias Ferreira, J (Autor) Outra; Sanchez Lopez, E (Autor) Outra; Cardoso, JC (Autor) Outra; Severino, P (Autor) Outra; Souto, EB (Autor) Outra

Revista

Título: Pharmaceutical Development and Technology

Páginas: 1-9

ISSN: 1083-7450

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 3 Citações

Outras Informações

ID Authenticus: P-00S-W09

DOI: 10.1080/10837450.2020.1839495

Abstract (EN): Isradipine is a dihydropyridine calcium channel blocker (CCB) commonly used as vasodilator with antihypertensive properties. A remote-controlled release formulation for isradipine would substantially improve the clinical outcomes of the patients requiring chronic long-term treatment. In this work, sustained release (SR) tablets of isradipine, composed of hydroxypropylmethyl cellulose (HPMC), have been produced by wet granulation and their in vitro and in vivo characterization was compared to a conventional tablet dosage form of immediate release (IR) as preliminary assessment. Tablets composed of 15.0% (wt/wt) HPMC exhibited a SR profile over a period of 24 hours. The release of isradipine followed a Fickian diffusion pattern obeying to the first order kinetics and the extent of absorption was even higher in comparison to the developed conventional tablets, which showed immediate drug release. In vivo studies were carried out in rabbits, showing that the extent of isradipine absorption from the developed tablets was higher in comparison to IR tablets due to the modified release profile obtained for the former (p < 0.05). Our results suggest that SR tablets of isradipine are an efficient solid dosage form to overcome the limitations encountered in conventional IR tablets.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9