Primary Humoral Immune Deficiencies: Overlooked Mimickers of Chronic Immune-Mediated Gastrointestinal Diseases in Adults

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Malesza, IJ (Autor) Outra; Malesza, M (Autor) Outra; Krela Kazmierczak, I (Autor) Outra; Zielinska, A (Autor) Outra; Souto, EB (Autor) Outra; Dobrowolska, A (Autor) Outra; Eder, P (Autor) Outra

Revista

Título: International Journal Of Molecular Sciences

Vol. 21 Nº 7

Páginas: 1-42

ISSN: 1661-6596

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 1 Citação

Classificação Científica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-00S-GY4

DOI: 10.3390/ijms21155223

Abstract (EN): In recent years, the incidence of immune-mediated gastrointestinal disorders, including celiac disease (CeD) and inflammatory bowel disease (IBD), is increasingly growing worldwide. This generates a need to elucidate the conditions that may compromise the diagnosis and treatment of such gastrointestinal disorders. It is well established that primary immunodeficiencies (PIDs) exhibit gastrointestinal manifestations and mimic other diseases, including CeD and IBD. PIDs are often considered pediatric ailments, whereas between 25 and 45% of PIDs are diagnosed in adults. The most common PIDs in adults are the selective immunoglobulin A deficiency (SIgAD) and the common variable immunodeficiency (CVID). A trend to autoimmunity occurs, while gastrointestinal disorders are common in both diseases. Besides, the occurrence of CeD and IBD in SIgAD/CVID patients is significantly higher than in the general population. However, some differences concerning diagnostics and management between enteropathy/colitis in PIDs, as compared to idiopathic forms of CeD/IBD, have been described. There is an ongoing discussion whether CeD and IBD in CVID patients should be considered a true CeD and IBD or just CeD-like and IBD-like diseases. This review addresses the current state of the art of the most common primary immunodeficiencies in adults and co-occurring CeD and IBD.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 42