Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Esteruelas, G (Autor) Outra; Souto, EB (Autor) FFUP; Espina, M (Autor) Outra; Garcia, ML (Autor) Outra; Switalska, M (Autor) Outra; Wietrzyk, J (Autor) Outra; Gliszczynska, A (Autor) Outra; Sanchez Lopez, E (Autor) Outra

Revista

Título: Pharmaceutics

Vol. 15

Página Final: 102

ISSN: 1999-4923

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00X-VBV

DOI: 10.3390/pharmaceutics15010102

Abstract (EN): Cancer is identified as one of the main causes of death worldwide, and an effective treatment that can reduce/eliminate serious adverse effects is still an unmet medical need. Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), has demonstrated promising antitumoral properties. However, the prolonged use of this NSAID poses several adverse effects. These can be overcome by the use of suitable delivery systems that are able to provide a controlled delivery of the payload. In this study, Diclofenac was incorporated into biodegradable polymeric nanoparticles based on PLGA and the formulation was optimized using a factorial design approach. A monodisperse nanoparticle population was obtained with a mean size of ca. 150 nm and negative surface charge. The release profile of diclofenac from the optimal formulation followed a prolonged release kinetics. Diclofenac nanoparticles demonstrated antitumoral and antiangiogenic properties without causing cytotoxicity to non-tumoral cells, and can be pointed out as a safe, promising and innovative nanoparticle-based formulation with potential antitumoral effects.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14