The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Neto, AC (Autor) Outra; Santos Pereira, M (Autor) Outra; Abreu Mendes, P (Autor) Outra; Neves, D (Autor) Outra; Almeida, H (Autor) Outra; Cruz, F (Autor) Outra; Charrua A. (Autor) FMUP

Revista

Título: Biomedicines

Vol. 11

Página Final: 696

Editora: MDPI

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-00X-Z9E

DOI: 10.3390/biomedicines11030696

Abstract (EN): <jats:p>The different definitions of chronic pelvic/visceral pain used by international societies have changed over the years. These differences have a great impact on the way researchers study chronic pelvic/visceral pain. Recently, the role of systemic changes, including the role of the central nervous system, in the perpetuation and chronification of pelvic/visceral pain has gained weight. Consequently, researchers are using animal models that resemble those systemic changes rather than using models that are organ- or tissue-specific. In this review, we discuss the advantages and disadvantages of using bladder-centric and systemic models, enumerating some of the central nervous system changes and pain-related behaviors occurring in each model. We also present some drawbacks when using animal models and pain-related behavior tests and raise questions about possible, yet to be demonstrated, investigator-related bias. We also suggest new approaches to study chronic pelvic/visceral pain by refining existing animal models or using new ones.</jats:p>

Idioma: Inglês

Tipo (Avaliação Docente): Científica