Lactoferrin and Cancer Disease Prevention

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2009

Autores

Rodrigues, L (Autor) Outra; Teixeira, JA (Autor) Outra; Fernando Schmitt (Autor) FMUP; Paulsson, M (Autor) Outra; Mansson, HL (Autor) Outra

Revista

Título: Critical Reviews in Food Science and Nutrition

Vol. 49

Páginas: 203-217

ISSN: 1040-8398

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 62 Citações

Scopus - 77 Citações

Outras Informações

ID Authenticus: P-003-PJG

DOI: 10.1080/10408390701856157

Abstract (EN): Lactoferrin (LF) is an iron-binding glycoprotein that is composed of the transferrin family and is predominantly found in the products of the exocrine glands located in the gateways of the digestive, respiratory, and reproductive systems, suggesting a role in the non-specific defence against invading pathogens. Additionally, several physiological roles have been attributed to LF, namely regulation of iron homeostasis, host defence against infection and inflammation, regulation of cellular growth, and differentiation and protection against cancer development and metastasis. These findings have suggested LF's great potential therapeutic use in cancer disease prevention and/or treatment, namely as a chemopreventive agent. This review looks at the recent advances in understanding the mechanisms underlying the multifunctional roles of LF and future perspectives on its potential therapeutic applications.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15