New halogenated phenylcoumarins as tyrosinase inhibitors

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Matos, MJ (Autor) Outra; Santana, L (Autor) Outra; Uriarte, E (Autor) Outra; Delogu, G (Autor) Outra; Corda, M (Autor) Outra; Fadda, MB (Autor) Outra; Era, B (Autor) Outra; Fais, A (Autor) Outra

Revista

Título: Bioorganic and Medicinal Chemistry Letters

Vol. 21

Páginas: 3342-3345

ISSN: 0960-894X

Editora: Elsevier

Indexação

Scopus - 47 Citações

Outras Informações

ID Authenticus: P-00R-0MH

DOI: 10.1016/j.bmcl.2011.04.012

Abstract (EN): With the aim to find out structural features for the tyrosinase inhibitory activity, in the present communication we report the synthesis and pharmacological evaluation of a new series of phenylcoumarin derivatives with different number of hydroxyl or ether groups and bromo substituent in the scaffold. The synthesized compounds 5-12 were evaluated as mushroom tyrosinase inhibitors showing, two of them, lower IC 50 than the umbelliferone. Compound 12 (IC 50 = 215 ¿M) is the best tyrosinase inhibitor of this series.

Idioma: Inglês

Tipo (Avaliação Docente): Científica