Metabolic syndrome, adipokines and ghrelin in overweight and obese schoolchildren: results of a 1-year lifestyle intervention programme

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Carla Pedrosa (Autor) Outra; Bruno M P M Oliveira (Autor) FCNAUP; Isabel Albuquerque (Autor) Outra; Carlos Simoes Pereira (Autor) Outra; Maria Daniel Vaz de Almeida (Autor) Outra; Flora Correia (Autor) FCNAUP

Revista

Título: European Journal of Pediatrics

Vol. 170 Nº 4

Páginas: 483-492

ISSN: 0340-6199

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 35 Citações

ISI Web of Science

Scopus - 40 Citações

Pubmed / Medline

Current Contents

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Pediatria ; Ciências da Saúde > Ciências Médicas > Medicina > Doenças relacionadas com a nutrição

Outras Informações

ID Authenticus: P-002-SXK

DOI: 10.1007/s00431-010-1316-2

Abstract (EN): The aim of this study was to evaluate the effect of a lifestyle intervention programme (nutrition and exercise counselling) on metabolic syndrome (MS) components, adipokines (leptin, adiponectin) and ghrelin levels in overweight children. A total of 61 overweight children aged 7-9 years (>= 85th body mass index (BMI) percentile; 27 boys/34 girls) were randomly assigned and completed a 1-year individual (IT) or group-based treatment (GT). Anthropometric and biochemical parameters were assessed at baseline, at 6 months and at 1 year. Twenty-two normal weight children (< 85th BMI percentile; 7-9 years old; 13 boys/nine girls) were also evaluated at baseline. Insulin resistance (IR) was determined by the homeostasis model assessment of IR (HOMA-IR). Overweight children presented significantly higher blood pressure, triglycerides, apolipoprotein B, insulin, HOMA-IR, leptin, C-reactive protein and homocysteine levels, while apolipoprotein A-I was significantly lower. At baseline, MS was present in ten overweight children, of which only five maintained it at 1 year. Leptin and ghrelin levels were associated with IR and MS components. MS was predicted by apolipoprotein A-I, insulin and pre-puberty. The lifestyle intervention led to a significant improvement in standard deviation score of BMI, waist circumference/height ratio and lipid profile. Changes in insulin, HOMA-IR, leptin and adiponectin were not significant. Ghrelin behaved differently between IT and GT. The GT intervention seems to be more successful, with a decrease in BMI Z-score and an improvement of metabolic parameters. In conclusion, overweight children have multiple risk factors associated with MS. A lifestyle intervention programme seems to be an effective mean for reducing obesity and MS components and improving adipokines concentrations.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Notas: Epub 2010 Oct 19 <a href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord&KeyUT=000288512900010">Indexado na ISI Web of Science</a>

Nº de páginas: 10