Molecular cloning and characterization of two novel transport proteins from rat kidney

• Tipo: Artigo em Revista Científica Internacional
• Data: 1998

Autores

Schomig, E (Autor) Outra; Spitzenberger, F (Autor) Outra; Engelhardt, M (Autor) Outra; Martel, F (Autor) FMUP; Ording, N (Autor) Outra; Grundemann, D (Autor) Outra

Revista

Título: FEBS Letters

Vol. 425

Páginas: 79-86

ISSN: 0014-5793

Editora: Wiley-Blackwell

Indexação

Scopus - 85 Citações

Outras Informações

ID Authenticus: P-007-8B8

DOI: 10.1016/s0014-5793(98)00203-8

Abstract (EN): The recent cloning of renal transport systems for organic anions and cations (OAT1, OCT1, and OCT2) opened the possibility to search, via polymerase chain reaction (PCR) homology screening, for novel transport proteins. Two integral membrane proteins, UST1 and UST2, were cloned from rat kidney. RT-PCR revealed that UST1 is confined to the kidney whereas UST2 mRNA was detected in all tested tissues. Sequence analyses suggest that UST1 and UST2, together with four related transporters, comprise, within the major facilitator superfamily, a so far unrecognized transporter family, termed amphiphilic solute facilitator (ASF) family. Characteristic signatures for the ASF family were identified.

Idioma: Inglês

Tipo (Avaliação Docente): Científica