Spatiotemporal Control of Forkhead Binding to DNA Regulates the Meiotic Gene Expression Program

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Alves Rodrigues, I (Autor) Outra; Ferreira, PG (Autor) Outra; Moldon, A (Autor) Outra; Vivancos, AP (Autor) Outra; Hidalgo, E (Autor) Outra; Guigo, R (Autor) Outra; Ayte, J (Autor) Outra

Revista

Título: Cell Reports

Vol. 14

Páginas: 885-895

ISSN: 2211-1247

Editora: Elsevier

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 5 Citações

Classificação Científica

CORDIS: Ciências Naturais > Ciências biológicas > Biologia > Biologia computacional ; Ciências Naturais > Ciências biológicas > Biologia > Biologia molecular

FOS: Ciências exactas e naturais > Ciências biológicas ; Ciências exactas e naturais > Ciências da computação e da informação

Outras Informações

ID Authenticus: P-00K-4MC

DOI: 10.1016/j.celrep.2015.12.074

Abstract (EN): Meiosis is a differentiated program of the cell cycle that is characterized by high levels of recombination followed by two nuclear divisions. In fission yeast, the genetic program during meiosis is regulated at multiple levels, including transcription, mRNA stabilization, and splicing. Mei4 is a forkhead transcription factor that controls the expression of mid-meiotic genes. Here, we describe that Fkh2, another forkhead transcription factor that is essential for mitotic cell-cycle progression, also plays a pivotal role in the control of meiosis. Fkh2 binding preexists in most Mei4-dependent genes, inhibiting their expression. During meiosis, Fkh2 is phosphorylated in a CDK/Cig2-dependent manner, decreasing its affinity for DNA, which creates a window of opportunity for Mei4 binding to its target genes. We propose that Fkh2 serves as a placeholder until the later appearance of Mei4 with a higher affinity for DNA that induces the expression of a subset of meiotic genes.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11