Anticancer activity of palladium-based complexes against triple-negative breast cancer

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2019

Autores

Vojtek, M (Autor) Outra; Marques, MPM (Autor) Outra; Ferreira, IMPLVO (Autor) Outra; Mota Filipe, H (Autor) Outra; Diniz, C (Autor) FFUP

Revista

Título: Drug Discovery Today

Vol. 24

Páginas: 1044-1058

ISSN: 1359-6446

Editora: Elsevier

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 36 Citações

Classificação Científica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-00Q-DZV

DOI: 10.1016/j.drudis.2019.02.012

Abstract (EN): Treatment of triple-negative breast carcinoma (TNBC) remains an unmet medical need with no targeted therapy available to date. Accounting for 10-30% of all human breast cancer tumors, this mammary carcinoma subtype has a particularly poor prognosis owing to its high metastatic potential, aggressive biology and limited pharmacological treatment options. Platinum chemotherapeutics are the mainstay therapy in patients with TNBC but their clinical use is limited by severe toxicity and acquired resistance. Palladium-based complexes are appealing alternative metal-based drugs because of significant similarities regarding structure and coordination chemistry with the platinum agents. This review summarizes the knowledge gathered so far on 121 Pd(II) complexes, emphasizing their anticancer activity and putative pharmacological targets toward TNBC.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15