Small Molecules Targeting Mutant P53: A Promising Approach for Cancer Treatment

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2019

Autores

Lopes, EA (Autor) Outra; Gomes, S (Autor) Outra; Lucilia Saraiva (Autor) FFUP; Santos, MMM (Autor) Outra

Revista

Título: Current Medicinal Chemistry

Vol. 26

Páginas: 7323-7336

ISSN: 0929-8673

Editora: Bentham Science

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 6 Citações

Outras Informações

ID Authenticus: P-00R-KE4

DOI: 10.2174/0929867325666181116124308

Abstract (EN): More than half of all human tumors express mutant forms of p53, with the ovary, lung, pancreas, and colorectal cancers among the tumor types that display the highest prevalence of p53 mutations. In addition, the expression of mutant forms of p53 in tumors is associated with poor prognosis due to increased chemoresistance and invasiveness. Therefore, the pharmacological restoration of wild-type-like activity to mutant p53 arises as a promising therapeutic strategy against cancer. This review is focused on the most relevant mutant p53 small molecule reactivators described to date. Despite some of them have entered into clinical trials, none has reached the clinic, which emphasizes that new pharmacological alternatives, particularly with higher selectivity and lower adverse toxic side effects, are still required.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14