Interictal spike EEG source analysis in hypothalamic hamartoma epilepsy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2002

Autores

Leal, AJR (Autor) Outra; Passao, V (Autor) Outra; Calado, E (Autor) Outra; Vieira, JP (Autor) Outra; Cunha, JPS (Autor) Outra

Revista

Título: Clinical Neurophysiology

Vol. 113

Páginas: 1961-1969

ISSN: 1388-2457

Editora: Elsevier

Indexação

ISI Web of Knowledge - 21 Citações

Scopus - 27 Citações

Outras Informações

ID Authenticus: P-000-M5K

DOI: 10.1016/s1388-2457(02)00253-5

Abstract (EN): Objective: The epilepsy associated with the hypothalamic hamartomas constitutes a syndrome with peculiar seizures, usually refractory to medical therapy, mild cognitive delay, behavioural problems and multifocal spike activity in the scalp electroencephalogram (EEG). The cortical origin of spikes has been widely assumed but not specifically demonstrated. Methods: We present results of a source analysis of interictal spikes from 4 patients (age 2-25 years) with epilepsy and hypothalamic hamartoma, using EEG scalp recordings (32 electrodes) and realistic boundary element models constructed from volumetric magnetic resonance imaging (MRIs). Multifocal spike activity was the most common finding, distributed mainly over the frontal and temporal lobes. A spike classification based on scalp topography was done and averaging within each class performed to improve the signal to noise ratio. Single moving dipole models were used, as well as the Rap-MUSIC algorithm. Results: All spikes with good signal to noise ratio were best explained by initial deep sources in the neighbourhood of the hamartoma, with late sources located in the cortex. Not a single patient could have his spike activity explained by a combination of cortical sources. Conclusions: Overall, the results demonstrate a consistent origin of spike activity in the subcortical region in the neighbourhood of the hamartoma, with late spread to cortical areas.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9