Ghrelin and ghrelin receptor inhibitors: agents in the treatment of obesity

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2008

Autores

Soares, JB (Autor) Outra; Roncon-Albuquerque R Jr (Autor) FMUP; Leite-Moreira AF (Autor) FMUP

Revista

Título: Expert Opinion on Therapeutic Targets

Vol. 12 Nº 9

Páginas: 1177-1189

ISSN: 1472-8222

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 33 Citações

Outras Informações

ID Authenticus: P-003-WFY

DOI: 10.1517/14728220802303039

Abstract (EN): Background: Current medical treatment of obesity is highly ineffective. Soon after its discovery as the endogenous ligand for the growth hormone secretagogue-receptor (GHS-R), ghrelin was shown to stimulate food intake (including in humans) and promote body weight gain and adipogenesis. Objectives: This review discusses the role of the ghrelin/GHS-R pathway in energy homeostasis regulation and its role as a novel molecular target for the treatment of obesity. Methods: Medline was searched for relevant articles published in English. Results/conclusion: A large series of animal studies shows that inhibition of the ghrelin/GHS-R pathway reduces food intake, body weight and adiposity, through reduction of appetite and augmentation of energy expenditure and fat catabolism. This suggests that inhibition of this novel pathway may be used to treat/prevent obesity and its complications.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13