Physiological, pathological and potential therapeutic roles of ghrelin

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2007

Autores

Leite-Moreira AF (Autor) FMUP; Soares, JB (Autor) Outra

Revista

Título: Drug Discovery Today

Vol. 12 Nº 23

Páginas: 276-288

ISSN: 1359-6446

Editora: Elsevier

Indexação

ISI Web of Knowledge - 116 Citações

Scopus - 120 Citações

Outras Informações

ID Authenticus: P-004-ASJ

DOI: 10.1016/j.drudis.2007.02.009

Abstract (EN): Ghrelin, a hormone that is produced mainly by the stomach, was identified originally as the endogenous ligand of the growth hormone secretagogue (GHS) receptor. Ghrelin might also be synthesized in other organs, where it might have autocrine or paracrine effects. GHS receptors are present in tissues other than the hypothalamus and pituitary, which indicates that ghrelin has other effects in addition to stimulating the release of growth hormone. Recently, it has been suggested that ghrelin might be involved in the pathogenesis of many diseases and be a therapeutic target in these diseases. Here, we provide an overview of the physiological effects of ghrelin and of its pathological and potential therapeutic roles.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13