Tetracycline, oxytetracycline and chlortetracycline complexation with copper (II). Potentiometric study [Complexação da tetraciclina, da oxitetraciclina e da clortetraciclina com o catião cobre (II). Estudo potenciométrico]

• Tipo: Artigo em Revista Científica Internacional
• Data: 2000

Autores

Couto, CMCM (Autor) Outra; Montenegro, MCBS (Autor) FFUP; Reis, S (Autor) FFUP

Revista

Título: Quimica Nova

Vol. 23

Páginas: 457-460

ISSN: 0100-4042

Editora: Sociedade Brasileira de Quimica

Indexação

ISI Web of Knowledge

Scopus - 14 Citações

Outras Informações

ID Authenticus: P-007-BSY

Abstract (EN): Stability constants of complexes formed by copper (II) with three different tetracyclines (tetracycline, oxytetracycline and chlortetracycline) have been determined potentiometrically with an automatic system in aqueous medium at 25,0 ± 0,2 °C and I = 0,1 mol L-1 NaNO3. The protonation constants of the three tetracyclines were also determined under the same conditions. The distribution of the complexes was then simulated at therapeutic levels of the drugs.

Idioma: Português

Tipo (Avaliação Docente): Científica