Fetal Undernutrition Modifies Vascular RAS Balance Enhancing Oxidative Damage and Contributing to Remodeling

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Vieira Rocha, MS (Autor) Outra; Rodriguez Rodriguez, P (Autor) Outra; Ferreira Duarte, M (Autor) Outra; Faria, M (Autor) Outra; Sousa, JB (Autor) Outra; Morato, M (Autor) FFUP; Arribas, SM (Autor) Outra; Diniz, C (Autor) FFUP

Revista

Título: International Journal Of Molecular Sciences

Vol. 23

Página Final: 1233

ISSN: 1661-6596

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00W-07S

DOI: 10.3390/ijms23031233

Abstract (EN): Fetal stress is known to increase susceptibility to cardiometabolic diseases and hypertension in adult age in a process known as fetal programming. This study investigated the relationship between vascular RAS, oxidative damage and remodeling in fetal programming. Six-month old Sprague-Dawley offspring from mothers that were fed ad libitum (CONTROL) or with 50% intake during the second half of gestation (maternal undernutrition, MUN) were used. qPCR or immunohistochemistry were used to obtain the expression of receptors and enzymes. Plasma levels of carbonyls were measured by spectrophotometry. In mesenteric arteries from MUN rats we detected an upregulation of ACE, ACE2, AT(1) receptors and NADPH oxidase, and lower expression of AT(2), Mas and MrgD receptors compared to CONTROL. Systolic and diastolic blood pressure and plasma levels of carbonyls were higher in MUN than in CONTROL. Vascular morphology evidenced an increased media/lumen ratio and adventitia/lumen ratio, and more connective tissue in MUN compared to CONTROL. In conclusion, fetal undernutrition indices RAS alterations and oxidative damage which may contribute to the remodeling of mesenteric arteries, and increase the risk of adverse cardiovascular events and hypertension.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 17