Nano- and Microdelivery Systems for Marine Bioactive Lipids

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

David M Pereira (Autor) FFUP; Patricia Valentao (Autor) FFUP; Paula B Andrade (Autor) FFUP

Revista

Título: Marine Drugs

Vol. 12

Páginas: 6014-6027

ISSN: 1660-3397

Editora: MDPI

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 9 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-00A-2DR

DOI: 10.3390/md12126014

Abstract (EN): There is an increasing body of evidence of the positive impact of several marine lipids on human health. These compounds, which include omega-3 polyunsaturated fatty acids, have been shown to improve blood lipid profiles and exert anti-inflammatory and cardioprotective effects. The high instability of these compounds to oxidative deterioration and their hydrophobicity have a drastic impact in their pharmacokinetics. Thus, the bioavailability of these compounds may be affected, resulting in their inability to reach the target sites at effective concentrations. In this regard, micro/nanoparticles can offer a wide range of solutions that can prevent the degradation of targeted molecules, increase their absorption, uptake and bioavailability. In this work we will present the options currently available concerning micro- and nanodelivery systems for marine lipids; with emphasis on micro/nanoparticles; such as micro/nanocapsules and emulsions. A wide range of bottom-up approaches using casein, chitosan, cyclodextrins, among others; will be discussed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14