Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Zegre, M (Autor) Outra; Barros, J (Autor) Outra; Ribeiro, IAC (Autor) Outra; Santos, C (Autor) Outra; Caetano, LA (Autor) Outra; Goncalves, L (Autor) Outra; Fernando Mendes Monteiro (Autor) FEUP; Ferraz, MP (Autor) FEUP; Bettencourt, A (Autor) Outra

Revista

Título: International Journal of Pharmaceutics

Vol. 622

ISSN: 0378-5173

Editora: Elsevier

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 6 Citações

Classificação Científica

CORDIS: Ciências da Saúde ; Ciências Tecnológicas

FOS: Ciências da engenharia e tecnologias ; Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-00W-JSS

DOI: 10.1016/j.ijpharm.2022.121832

Abstract (EN): New strategies for the treatment of polymicrobial bone infections are required. In this study, the co-delivery of two antimicrobials by poly(D,L-lactic acid) (PDLLA) scaffolds was investigated in a polymicrobial biofilm model. PDLLA scaffolds were prepared by solvent casting/particulate leaching methodology, incorporating minocycline and voriconazole as clinically relevant antimicrobial agents. The scaffolds presented a sponge-like appearance, suitable to support cell proliferation and drug release. Single- and dual-species biofilm models of Staphylococcus aureus and Candida albicans were developed and characterized. S. aureus presented a higher ability to form singlespecies biofilms, compared to C. albicans. Minocycline and voriconazole-loaded PDLLA scaffolds showed activity against S. aureus and C. albicans single- and dual-biofilms. Ultimately, the cytocompatibility/functional activity of PDLLA scaffolds observed in human MG-63 osteosarcoma cells unveil their potential as a next-generation codelivery system for antimicrobial therapy in bone infections.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12