Sodium Tripolyphosphate: An excipient with intrinsic in vitro anti-Candida activity

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Palmeira de Oliveira, R (Autor) Outra; Palmeira de Oliveira, A (Autor) Outra; Gaspar, C (Autor) Outra; Silvestre, S (Autor) Outra; Martinez de Oliveira, J (Autor) Outra; Amaral, MH (Autor) FFUP; Breitenfeld, L (Autor) Outra

Revista

Título: International Journal of Pharmaceutics

Vol. 421

Páginas: 130-134

ISSN: 0378-5173

Editora: Elsevier

Indexação

ISI Web of Knowledge - 14 Citações

Scopus - 20 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-002-HRD

DOI: 10.1016/j.ijpharm.2011.09.030

Abstract (EN): Sodium Tripolyphosphate (STPP) is a food additive that is being used in the development of micro and nanoparticles as it induces ionic interactions with chitosan molecules. Although the ability of STPP to inhibit the growth of several food contaminants has been reported, studies on its activity against clinical isolates are scarce. Candida spp. are common causative agents of mucocutaneous infections including the vulvovaginal tegument and new therapeutic approaches are needed in order to treat resistant and recurrent cases. The aim of this study was to evaluate in vitro both antifungal (anti-Candida spp.) activity, and cytotoxicity, on human dermal fibroblasts, of STPP solutions. STPP showed an inhibitory species-dependent activity against several Candida spp. strains being particularly active on C. glabrata, followed by C. guilliermondii. In vitro, STPP showed a concentration dependent cytotoxicity. Therefore STPP use, in low concentrations, seems to be interesting in the development of drug delivery systems for the treatment of vulvovaginal candidosis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5