Sensibility of the quorum growth thresholds controlling local immune responses

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Burroughs, NJ (Author) Other; Bruno M P M Oliveira (Author) FCNAUP; Alberto A. Pinto (Author) Other; Sequeira, HJT (Author) Other

Journal

Title: Mathematical and Computer Modelling

Vol. 47 No. 7

Pages: 714-725

ISSN: 0895-7177

Publisher: Pergamon Press - Elsevier

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-004-0N3

DOI: 10.1016/j.mcm.2007.06.007

Abstract (EN): The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immune responses develop on activation and whether the immune system returns to a control state. We study the effects in the quorum T cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the value of the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12