Sensibility of the quorum growth thresholds controlling local immune responses

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Burroughs, N.J. (Author) Other; Oliveira, Bruno (Author) FCNAUP; Pinto, Alberto Adrego (Author) Other; Sequeira, H.J. (Author) Other

Journal

Title: Mathematical and Computer Modelling

Vol. 47 No. 7

Pages: 714-725

ISSN: 0895-7177

Publisher: Pergamon Press Ltd.

Indexing

ISI Web of Knowledge - 14 Citations

ISI Web of Science

Scopus - 14 Citations

Scientific classification

FOS: Natural sciences > Mathematics

CORDIS: Health sciences > Medical sciences > Medicine > Immunology ; Physical sciences > Mathematics > Applied mathematics

Other information

Authenticus ID: P-004-0N3

DOI: 10.1016/j.mcm.2007.06.007

Abstract (EN): The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immune responses develop on activation and whether the immune system returns to a control state. We study the effects in the quorum T cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the value of the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12