Atrial natriuretic factor and changes in the aldosterone response to angiotensin II in sodium depleted dogs

• Tipo: Artigo em Revista Científica Internacional
• Data: 1993

Autores

Richards, AM (Autor) Outra; Tree, M (Autor) Outra; Tonolo, G (Autor) Outra; Montorsi, P (Autor) Outra; Polonia, J (Autor) FMUP; Morton, JJ (Autor) Outra; Fraser, R (Autor) Outra; Frampton, C (Autor) Outra

Revista

Título: Clinical and Experimental Hypertension

Vol. 15

Páginas: 379-394

ISSN: 1064-1963

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-008-PVZ

DOI: 10.3109/10641969309032941

Abstract (EN): The effects of physiological shifts in plasma atrial natriuretic factor (ANF) concentrations on angiotensin II/aldosterone relationships during changes in sodium status were assessed in 6 conscious beagle dogs. Incremental infusions of angiotensin II (3, 9 and 27 ng/kg/min) were administered on three occasions. The animals were studied in sodium replete and deplete states and on a third occasion, again while sodium deplete, with a background constant low-dose infusion of ANF (1.5 pmol/kg/min) sufficient to enhance the low endogenous plasma ANF values observed in sodium depletion to match those observed in the sodium replete state. Sodium depletion caused a leftward shift and steepened the slope of the relationship between achieved arterial angiotensin II concentrations and the plasma aldosterone response. This effect was significantly attenuated (approximately 50%) by the low dose ANF infusions which tended to flatten the slope of the angiotensin II/aldosterone curve (ns) and shifted it significantly to the right (p < 0.05). These data suggest subtle shifts in endogenous levels of plasma ANF, accompanying changes in sodium status, are a major contributor to the associated alterations in angiotensin II/aldosterone relationships. Low dose ANF also significantly reduced the effect of angiotensin II on arterial pressures did not alter natriuresis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16