Catechols from abietic acid: Synthesis and evaluation as bioactive compounds

• Tipo: Artigo em Revista Científica Internacional
• Data: 2003

Autores

Gigante, B (Autor) Outra; Santos, C (Autor) Outra; Silva, AM (Autor) Outra; Curto, MJM (Autor) Outra; Nascimento, MSJ (Autor) FFUP; Pinto, E (Autor) FFUP; Pedro, M (Autor) Outra; Cerqueira, F (Autor) Outra; Pinto, MM (Autor) FFUP; Duarte, MP (Autor) Outra; Laires, A (Autor) Outra; Rueff, J (Autor) Outra; Goncalves, J (Autor) FFUP; Pegado, MI (Autor) Outra; Valdeira, ML (Autor) Outra

Revista

Título: Bioorganic and Medicinal Chemistry

Vol. 11

Páginas: 1631-1638

ISSN: 0968-0896

Editora: Elsevier

Indexação

ISI Proceedings

ISI Web of Knowledge - 89 Citações

Scopus - 97 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-000-H1X

DOI: 10.1016/s0968-0896(03)00063-4

Abstract (EN): Catechols from abietic acid were prepared by a short and good yielding chemical process and further evaluated for several biological activities namely, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative and inhibition of nitric oxide. Their properties were compared with those of carnosic acid (6), a naturally occurring catechol with an abietane skeleton and known to possess potent antioxidant activity, as well as anticancer and antiviral properties. From all the synthetic catechols tested compound 2 showed the best activities, stronger than carnosic acid.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8