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Molecular Toxicology

Code: M.BIO030     Acronym: TM

Keywords
Classification Keyword
OFICIAL Molecular Bioengineering

Instance: 2024/2025 - 2S (of 17-02-2025 to 18-07-2025) Ícone do Moodle

Active? Yes
Responsible unit: Population Studies
Course/CS Responsible: Master in Bioengineering

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
M.BIO 13 Syllabus 1 - 6 39 162

Teaching Staff - Responsibilities

Teacher Responsibility
Lúcia Maria das Candeias Guilhermino

Teaching - Hours

Theoretical and practical : 3,00
Type Teacher Classes Hour
Theoretical and practical Totals 1 3,00
Félix Dias Carvalho 0,25
João Paulo Fernandes Teixeira 1,00
Lúcia Maria das Candeias Guilhermino 1,00

Teaching language

Portuguese

Objectives

- get fundamental and applied competences and skills in toxicology and ecotoxicology

 

Learning outcomes and competences

- get fundamental and applied competences and skills in toxicology and ecotoxicology

- develop the capability of  search, select and summarise scientific and technical information

- develop the autonomy, and the ability of work in a team and integration of knowledge from different areas to approach and solve fundamental and applied problems and questions

- develop the capability and skills for science communication to different types of audience

 

 

Working method

Presencial

Program

I

- Objectives, scope and definition of Toxicology and Ecotoxicology

- Diferent branches of Toxicology: mechanistic, clinical,  regulatory, environmental, …

- Concepts in Toxicology

- Factors influencing the toxicity

- Introduction to risk assessment

 

II

Cinetics of xenobiotics in the organism and factors influencing the processes

- absorption

- distribution

- metabolism and bioactivation

- elimination

 

Fate of xenobiotics and natural toxins in the environment

- sources and routes by which xenobiotics enter into the environment

- environmental fate and degradation

- interactions with the abiotic component of the ecosystems

- interactions with the ecosystem biotic component  (e.g. bioaccumulation, biomagnification, ecotoxicological effects)

- changes at the ecosystem level and implications for human and environmental health  

 

III

Mechanisms of toxicity: from the molecule to the ecosystem

 

IV

The Toxicology in the XXI century

- models for toxicity evaluation:  in vitro versus in vivo studies

- toxicology of systems

- toxicogenomics and toxicoproteomics

 

V

New molecules and new materials: challenges for Toxicology and Ecotoxicology

Biomarkers in Toxicology and Ecotoxicology

 

 

Mandatory literature

Klaassen Curtis D. ed.; Casarett and Doull.s toxicology. ISBN: 0-07-105476-6
Walker C. H. 070; Principles of ecotoxicology. ISBN: 0-8493-3635-X
Timbrell John; Principles of biochemical toxicology. ISBN: 0-748-40736-7
Timbrell John; Introduction to toxicology. ISBN: 0-415-24762-4

Comments from the literature

several websites and scientific papers

Teaching methods and learning activities

interactive lectures and traning sessions involving the students as much as possible; these will be complemented with autonomous work by the students 

keywords

Natural sciences > Environmental science > Ecology > Ecotoxicology
Health sciences > Pharmacological sciences > Toicology
Natural sciences > Environmental science > Ecology > Environmental risks
Natural sciences > Environmental science > Ecology

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation Weight (%)
Apresentação/discussão de um trabalho científico 15,00
Exame 75,00
Participação presencial 5,00
Prova oral 5,00
Total: 100,00

Amount of time allocated to each course unit

Designation Time (hours)
Apresentação/discussão de um trabalho científico 8,00
Estudo autónomo 112,00
Frequência das aulas 42,00
Total: 162,00

Eligibility for exams

A. Minimum of 7,5 out of 15 in the final exam.
B. minimum of 1.0 out of 2.0 in the evaluation of the activities carried out in classes complemented with authonomous work.
C. Minimum of 1.5 out of 3.0 in the seminary component.

Calculation formula of final grade

The final mark (FM) is the sum of the partial records obtained in the following items (to a total of 20 points):

A. Final exam: up to 15.0 with a compulsory minimum of 7.5 points.

B. Participation in the activities carried out along the semester complemen: up to 2.0 points.

C. Seminary component (autonomous group work with platform and poster presentation at the end of the semester): up to 3.0 points.

FM = A + B + C

Examinations or Special Assignments

team work about a topic in the scope of the curricular unit

Classification improvement

exam

Observations

If not possible to make the exam at ICBAS facilities, the evaluation will be done through the continuous evaluation and the seminar component.
The improvement of the mark obtained in the first period of evaluation can be made through the improvement of seminar work.

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