Biomaterials and Engineering of Biomimetic Matrices

Code:

EBE0219

Acronym:

BEMB

Keywords
Classification	Keyword
OFICIAL	Molecular Biotechnology

Instance: 2019/2020 - 2S

Active?	Yes
Responsible unit:	Molecular Biology
Course/CS Responsible:	Master in Bioengineering

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIB	27	Syllabus	3	-	6	56	162

Teaching language

Suitable for English-speaking students

Objectives

To provide fundamental principles on Biomaterials Science and Engineering and state of the art knowledge on biomaterials development, in particular for the most relevant medical applications.

The range of biomaterials (the “biomaterials toolbox”) available for clinical application is very wide, ranging from traditional to nanobioengineered materials.

Many of the most spectacular and promising strategies for tissue repair and regeneration stem from a deep understanding of the structure and function of the extracellular matrix (ECM) and its components. The ECM is formidable source of inspiration in the development of biomimetic biomaterials.

Learning outcomes and competences

It is expected that the students will acquire the following skills:

1) Ability to integrate knowledge on how natural and artificial biomaterials/matrices interact with their biological environment.

2) Critical analysis of published data, during presentation and discussion of research papers

3) Capacity to formuate objective and structured questions

Working method

Presencial

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

None

Program

1) Fundamentals and evolutiion of Biomaterials

2) Types of biomaterials and applications (the biomaterials toolbox) 

3) The extra-cellular matrix as a source of inspiration for bioengineered materials. Biomimetic matrices

4) Technologies for production of biomaterials for tissue repair and regeneration.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Mandatory literature

Ratner, Buddy D.; Biomaterials Science, Third Edition: An Introduction to Materials in Medicine, 2012. ISBN: 978-0123746269
2. M. Agrawal, J. L. Ong, M. R. Appleford and G. Mani; Introduction to Biomaterials Basic Theory with Engineering Applications, Cambridge University Press, 2014. ISBN: 978-0-521-11690-9
Kay C. Dee, David A. Puleo, Rena Bizios ; An Introduction to Tissue-Biomaterial Interactions, 2002. ISBN: 978-0471253945
L. Di Silvio (Editor) ; Cellular Response to Biomaterials, Woodhead Publishing in Materials, 2009. ISBN: 978-1420093735

Complementary Bibliography

Johnna S. Temenoff, Antonios G. Mikos; Biomaterials, The Intersection of Biology and Materials Science, Pearson Prentice Hall Bioengineering, 2008. ISBN: 978-0130097101
P Ducheyne (Editor in Chief); Comprehensive Biomaterials , 2011. ISBN: ISBN: 978-0-08-055294-1
Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter ; Molecular Biology of the Cell, 2007. ISBN: 978-0815341055

Teaching methods and learning activities

The program is focused on medical applications (e.g. pacemakers, orthopaedic and dental materials, nervous system) that are the motto for the integration of knowledge. In addition to the presentation of fundamental concepts,by the lecturer, the students present and discuss research articles/review. The selection is done collectively, based on students proposals, with each paper covering a different medical application. The presentation of each paper is done by a group of students, during 10 min. A disscussion follows by all the class, being led by a group of students. A third component consists of the presentation of questions previously written by students and answered in class, in writing, by the students.

Experiments relevant to this course will be carried out in lab sessions that are organized with other courses run in the same semestre for the same students, with the purpose of integrating knowledge.

Evaluation Type

Evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	50,00
Participação presencial	20,00
Trabalho laboratorial	20,00
Apresentação/discussão de um trabalho científico	10,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	30,00
Frequência das aulas	70,00
Trabalho laboratorial	20,00
Total:	120,00

Eligibility for exams

A mark equal or above 10 in the laboratory work and at least equal to 8 in the theoretical component. 

Calculation formula of final grade

Final = Exam x 0.50 + Paper presentation x 0.10 + structured questions x 0.20 + lab work x 0.20