Molecular Toxicology

Code:

EBE0222

Acronym:

TOXMOL

Keywords
Classification	Keyword
OFICIAL	Molecular Biotechnology

Instance: 2018/2019 - 2S

Active?	Yes
Responsible unit:	Population Studies
Course/CS Responsible:	Master in Bioengineering

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIB	34	Syllabus	3	-	6	42	162

Teaching language

Portuguese

Objectives

- get fundamental and applied competences and skills in toxicology and ecotoxicology

 

Learning outcomes and competences

- get fundamental and applied competences and skills in toxicology and ecotoxicology

- develop the capability of  search, select and summarise scientific and technical information

- develop the autonomy, and the ability of work in a team and integration of knowledge from different areas to approach and solve fundamental and applied problems and questions

- develop the capability and skills for science communication to different types of audience

 

 

Working method

Presencial

Program

I

- Objectives, scope and definition of Toxicology and Ecotoxicology

- Diferent branches of Toxicology: mechanistic, clinical,  regulatory, environmental, …

- Concepts in Toxicology

- Factors influencing the toxicity

- Introduction to risk assessment

 

II

Cinetics of xenobiotics in the organism and factors influencing the processes

- absorption

- distribution

- metabolism and bioactivation

- elimination

 

Fate of xenobiotics and natural toxins in the environment

- sources and routes by which xenobiotics enter into the environment

- environmental fate and degradation

- interactions with the abiotic component of the ecosystems

- interactions with the ecosystem biotic component  (e.g. bioaccumulation, biomagnification, ecotoxicological effects)

- changes at the ecosystem level and implications for human and environmental health  

 

III

Mechanisms of toxicity: from the molecule to the ecosystem

 

IV

The Toxicology in the XXI century

- models for toxicity evaluation:  in vitro versus in vivo studies

- toxicology of systems

- toxicogenomics and toxicoproteomics

 

V

New molecules and new materials: challenges for Toxicology and Ecotoxicology

Biomarkers in Toxicology and Ecotoxicology

 

 

Mandatory literature

Klaassen Curtis D. ed.; Casarett and Doull.s toxicology. ISBN: 0-07-105476-6
Walker C. H. 070; Principles of ecotoxicology. ISBN: 0-8493-3635-X
Timbrell John; Principles of biochemical toxicology. ISBN: 0-748-40736-7
Timbrell John; Introduction to toxicology. ISBN: 0-415-24762-4

Comments from the literature

several websites and scientific papers

Teaching methods and learning activities

interactive lectures and traning sessions involving the students as much as possible; these will be complemented with autonomous work by the students 

keywords

Natural sciences > Environmental science > Ecology > Ecotoxicology
Health sciences > Pharmacological sciences > Toicology
Natural sciences > Environmental science > Ecology > Environmental risks
Natural sciences > Environmental science > Ecology

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Apresentação/discussão de um trabalho científico	15,00
Exame	75,00
Participação presencial	5,00
Prova oral	5,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Apresentação/discussão de um trabalho científico	8,00
Estudo autónomo	112,00
Frequência das aulas	42,00
Total:	162,00

Eligibility for exams

- minimum of 7,5 out of 15 in the final exam.
- minimum of 1.0 out of 2.0 in the continuous evaluation.
- minimum of 1.5 out of 3.0 in the seminary component.

Calculation formula of final grade

The final mark is the sum of the partial records obtained in the following items (to a total of 20 points): - Final exam: up to 15.0 with a compulsory minimum of 7.5 points. - Seminary component (autonomous group work with platform and poster presentation at the end of the semester): up to 3.0 points. - Participation in the activities done during the semester in the different types of sessions, including mini-tests: up to 2.0 points.

Examinations or Special Assignments

team work about a topic in the scope of the curricular unit

Classification improvement

exam