Veterinary Toxicology

Code:

MV416

Acronym:

TV

Keywords
Classification	Keyword
OFICIAL	Basic Sciences

Instance: 2008/2009 - 1S

Active?	Yes
Responsible unit:	Population Studies
Course/CS Responsible:	Integrated Masters Degree in Veterinary Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMV	55	Plan 2007 to 2017	4	-	4,5	64	121,5

Teaching language

Portuguese

Objectives

1. To provide fundamental concepts of Toxicology and Ecotoxicology and the contact with conventional methods and new approaches to overcome problems that students may have to face during their future professional activity. 2. To stimulate the skills of the students for scientific research and for the search of knowledge. 3. To develop the capability of working in group in an integrated and multi-disciplinary perspective. 4. To promote the use of the knowledge previously acquired in the scope of other courses to solve toxicological and ecotoxicological problems.

Program

I. FUNDAMENTAL TOXICOLOGY
1. Origins and evolution of Veterinary Toxicology. Toxicology and Ecotoxicology: Objectives and scopes. Possible areas of professional intervention.
2. Basic principles and fundamental concepts.
3. Fate of chemical agents (xenobiotics and natural substances) in the organism. Steps of the toxicological process.
4. Mixtures and toxicological interactions.
5. Dose(concentration) relationship. Toxicological parameters.
6. Toxicity tests.
7. Alternative methods to animal experimentation in toxicology.

II. CLINIC TOXICOLOGY
8. Circumstances leading to intoxications in domestic and wild animals.
9. Main agents involved in animal intoxications and poisoning. Modes of action and mechanisms of toxicity and detoxication. Species differences.
10. Diagnosis and treatment.

III. ECOTOXICOLOGY
11. Importance of Ecotoxicology in the actual context.
12. Effects of pollution on wildlife and on ecosystems.
13. Fate of xenobiotics and natural agents on ecosystems. Bioaccumulation and biomanignification of environmental contaminants. Primary and secondary poisoning in wildlife.
14. Assessment of ecotoxicological effects: objectives, principles and ecotoxicological parameters. Standard laboratorial bioassays (OCDE ecotoxicity tests). Other laboratorial bioassays. Micro, meso and macrocosm assays. In situ bioassays.
15. Chemical, biological and ecological monitoring of pollution.
16. Ecological Risk Assessment. European and national regulation of chemicals. REACH.

Mandatory literature

Rachel Carson; Silent Spring, 1962
Humphreys D. J.; Toxicologia veterinária. ISBN: 84-7615-469-0
Klaassen Curtis D. ed.; Casarett and Doull.s toxicology. ISBN: 0-07-105476-6
Ballantyne Bryan ed.; General & applied toxicology. ISBN: 1-56159-107-6
Rand, G.M. (ed.) ; Fundamentals of Aquatic Toxicology., Taylor & Francis, London
OECD ; OECD guidelines for the testing of chemicals. , Organisation for Economic Co-operation and development, Paris. (www.oecd.org), 1996
Guilhermino, L.; Origens e evolução da Toxicologia e da Ecotoxicologia, ICBAS, 2001
Colborn, T.; Dumanoski; Myers, J.P; Our Stolen Future. Are we threatening our Fertility, Intelligence and Survival? - a Scientific Detective Story. , Dutto, New York.New York. , 1996
Timbrell John; Introduction to toxicology. ISBN: 0-415-24762-4
Timbrell John; Principles of biochemical toxicology. ISBN: 0-748-40736-7
Beasley, V. (Ed.). ; Veterinary Toxicology, International Veterinary Information Service, Ithaca NY. (www.ivis.org), 1999.
Gfeller Roger W.; Handbook of small animal toxicology and poisonings. ISBN: 0-8151-6454-8
Walker C. H. 070; Principles of ecotoxicology. ISBN: 0-8493-3635-X
ULL; Handbook of ecotoxicology. ISBN: 0-87371-585-3
Walker C. H. 070; Principles of ecotoxicology. ISBN: 0-8493-3635-X
Rachel Carson; Silent Spring, 1962
Humphreys D. J.; Toxicologia veterinária. ISBN: 84-7615-469-0
Klaassen Curtis D. ed.; Casarett and Doull.s toxicology. ISBN: 0-07-105476-6
Ballantyne Bryan ed.; General & applied toxicology. ISBN: 1-56159-107-6
Rand, G.M. (ed.) ; Fundamentals of Aquatic Toxicology., Taylor & Francis, London
OECD ; OECD guidelines for the testing of chemicals. , Organisation for Economic Co-operation and development, Paris. (www.oecd.org), 1996
Guilhermino, L.; Origens e evolução da Toxicologia e da Ecotoxicologia, ICBAS, 2001
Colborn, T.; Dumanoski; Myers, J.P; Our Stolen Future. Are we threatening our Fertility, Intelligence and Survival? - a Scientific Detective Story. , Dutto, New York.New York. , 1996
Timbrell John; Introduction to toxicology. ISBN: 0-415-24762-4
Timbrell John; Principles of biochemical toxicology. ISBN: 0-748-40736-7
Beasley, V. (Ed.). ; Veterinary Toxicology, International Veterinary Information Service, Ithaca NY. (www.ivis.org), 1999.
Gfeller Roger W.; Handbook of small animal toxicology and poisonings. ISBN: 0-8151-6454-8
ULL; Handbook of ecotoxicology. ISBN: 0-87371-585-3

Teaching methods and learning activities

Integrative and interactive teaching, based on the development of competences. Theoretical lectures are complemented by theoretical-practical sessions and laboratorial work. Themes are presented to stimulate the interactive discussion with the students; some specific topics are discussed after independent search for information by the students. In laboratorial sessions and using a tutorial approach, students do toxicity and ecotoxicity experiments, perform the statistical analysis of data, discuss the results and present the results as scientific papers. Furthermore, there is a seminar component where students, working in groups of 2 to 4 elements, investigate autonomously a specific topic of their choice in the scope of the discipline; at the end of the semester they should produce a written report (as a revision paper), a poster and a platform presentation; in a session open to the Academic community, each group presents the results of its work to all the other students and to teachers; posters are shown to the academic community in an exhibition of above 1 month. In some years, students participate in congresses where they present the work developed in this component of the course.

Software

SPSS
SPSS
excel
excel

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Subject Classes	Participação presencial	72,00
	Total:	-	0,00

Eligibility for exams

1) An individual report, presented as a scientific paper review (Max 6 A4 pages), about a free chosen subject in the scope of the course.

2) Platform presentation of the work done (15 minutes + 5 for discussion).

3) Poster

Calculation formula of final grade

Final classification (max 20) is the sum of:

1. classification obtained in one individual report of a laboratorial work: maximum of 5 points
2. Classification obtained in the seminar component of the discipline (written report + poster + platform presentation): maximum 15 points

Observations

In the scope of the course, seminars by invited professors/researchers on specific topics are organized