Biological Responses to Biomaterials

Code:

EBE0221

Acronym:

RBB

Keywords
Classification	Keyword
OFICIAL	Molecular Biotechnology

Instance: 2013/2014 - 2S

Active?	Yes
Responsible unit:	Molecular Biology
Course/CS Responsible:	Master in Bioengineering

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIB	35	Syllabus	3	-	6	56	162

Teaching language

Suitable for English-speaking students

Objectives

The course focuses mainly on the cellular and molecular mechanisms that underlie the cell/tissue reactions to biomaterials as well as on the in vitro and in vivo methods applied for the tissue response evaluation. Articles from the current literature will be used to highlight the ongoing research in this field.

Learning outcomes and competences

Upon successful completion of this course, students will acquire knowledge on topics including cell /tissue behavior to biomaterials in terms of toxicity,
apoptosis, cell adhesion, cell proliferation, cell differentiation and cell-cell interactions. Furthermore, the students will gain critical analysis of animal models suitable for studying the different aspects of the biological reactions to biomaterials.

Working method

Presencial

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

Basic concepts of cell and molecular biology

Program

The course covers the following topics:
I- Cell response to Biomaterials
- Adhesion
- Proliferation
- Differentiation
- Apoptosis
II- Cellular Mechanisms involved in cell responses to Biomaterials
-Extracellular matrix
-Transduction pathways
III- Tissue response to biomaterials in vivo
-Animal models
-Biocompatibility
-Processes of Tissue regeneration

Mandatory literature

Wescoe KE, Schugar RC, Chu CR, Deasy BM.; The role of the biochemical and biophysiscal enviornment in chondrogenic stem cell differentiation assays and cartilage tissue engineering.
Muschler GF, Raut VP, Patterson TE, Wenke JC, Hollinger JO.; The design and use of animal models for translational research in bone tissue engineering and regenerative medecine,
Anderson JM, McNally AK.; Biocompatibility of implants: lymphocytes /macrophages intercations
Bran GM, Stern-Straeter J, Hörmann K, Riedel F, Goessler UR.; Apoptosis in bone for tissue engineering
Togashi H, Sakisaka T, Takai Y.; Cell adhesion molecules in central nervous system

Complementary Bibliography

Williams DF; On the mechanisms of biocompatibility
Koh TJ, DiPietro LA; Inflammation and wound healing: the role of macrophage

Teaching methods and learning activities

Aulas teóricas que compreende a exposição teórica, debate, apresentação e discussão de artigos com alunos. Em paralelo há uma componente laboratorial que permite aos alunos adquirir capacidades técnicas para
avaliação da resposta celular e molecular aos biomaterias

Evaluation Type

Evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	70,00
Participação presencial	5,00
Trabalho laboratorial	25,00
Total:	100,00

Calculation formula of final grade

Final grade= written exam (70% with minimum of 10 points) + class participation (5%) + Laboratory report (25% with minimum of 9 points)