Small Molecules as Chromatographic Tools for HPLC Enantiomeric Resolution: Pirkle-Type Chiral Stationary Phases Evolution

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2013

Autores

fernandes, c (Autor) FFUP; tiritan, me (Autor) Outra; pinto, m (Autor) FFUP

Revista

Título: Chromatographia

Vol. 76

Páginas: 871-897

ISSN: 0009-5893

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 46 Citações

Scopus - 45 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-006-8PF

DOI: 10.1007/s10337-013-2469-8

Abstract (EN): This review focuses on the evolution of Pirkle-type chiral stationary phases (CSPs), based on chiral recognition mechanism of small molecules and applications directly related with Medicinal Chemistry. Therefore, the strategies to plan these chiral selectors for enantioseparation of diverse therapeutic classes of chiral drugs and the understanding of the recognition mechanism are emphasized. The planning of Pirkle and co-workers to design different classes of CSPs was initially based on NMR studies, following the principle of reciprocity together with chromatographic results and studies of chiral recognition phenomena. All those features are described and critically discussed in this review. Finally, based on general principles established by Pirkle's work it can be inferred that diverse chiral small molecules can be successfully used as chromatographic tools for enantiomeric resolution. In this context, several research groups were inspired on Pirkle's design to develop new CSPs. Xanthone derivatives bonded to chiral groups were also exploited as selectors for CSPs and are briefly reported.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 27