Small Molecules as Chromatographic Tools for HPLC Enantiomeric Resolution: Pirkle-Type Chiral Stationary Phases Evolution

• Type: Another Publication in an International Scientific Journal
• Date: 2013

Authors

fernandes, c (Author) FFUP; tiritan, me (Author) Other; pinto, m (Author) FFUP

Journal

Title: Chromatographia

Vol. 76

Pages: 871-897

ISSN: 0009-5893

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 46 Citations

Scopus - 45 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-006-8PF

DOI: 10.1007/s10337-013-2469-8

Abstract (EN): This review focuses on the evolution of Pirkle-type chiral stationary phases (CSPs), based on chiral recognition mechanism of small molecules and applications directly related with Medicinal Chemistry. Therefore, the strategies to plan these chiral selectors for enantioseparation of diverse therapeutic classes of chiral drugs and the understanding of the recognition mechanism are emphasized. The planning of Pirkle and co-workers to design different classes of CSPs was initially based on NMR studies, following the principle of reciprocity together with chromatographic results and studies of chiral recognition phenomena. All those features are described and critically discussed in this review. Finally, based on general principles established by Pirkle's work it can be inferred that diverse chiral small molecules can be successfully used as chromatographic tools for enantiomeric resolution. In this context, several research groups were inspired on Pirkle's design to develop new CSPs. Xanthone derivatives bonded to chiral groups were also exploited as selectors for CSPs and are briefly reported.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 27