Design of microparticles containing natural antioxidants: Preparation, characterization and controlled release studies

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Joana Aguiar (Autor) FEUP; Raquel Costa (Autor) FEUP; F. Rocha (Autor) FEUP; B. N. Estevinho (Autor) FEUP; L. Santos (Autor) FEUP

Revista

Título: Powder Technology

Vol. 313

Páginas: 287-292

ISSN: 0032-5910

Editora: Elsevier

Indexação

ISI Web of Knowledge - 10 Citações

ISI Web of Science

Scopus - 31 Citações

INSPEC

Classificação Científica

FOS: Ciências da engenharia e tecnologias

Projetos Associados

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

LEPABE-2-ECO-INNOVATION - LEPABE-2-ECO-INNOVATION

Outras Informações

ID Authenticus: P-00M-H7V

DOI: 10.1016/j.powtec.2017.03.013

Abstract (EN): Antioxidants are important compounds in the prevention of diseases like cancer, diabetes, cardiovascular, neurodegenerative diseases and premature aging, however they are very sensitive to the light, heat, oxygen and pH. In this study, caffeic acid (CAF), chlorogenic acid (CGA) and rosmarinic acid (RA), 3 natural antioxidants, were encapsulated by spray-drying using sodium carboxymethyl cellulose (Na-CMC) to overcome their limitations in industrial applications. Product yield values were around 40% and the encapsulation efficiency values were higher than 90%. Particles revealed a smooth spherical shape with mean diameter below 11 ¿m (considering volume size distribution). Microparticles loaded with CAF, CGA and RA were fully released after 45 min, 2 h and 4 h, respectively. Antioxidant activity was not compromised, highlighting the potential of spray-dried Na-CMC microparticles as carriers of natural antioxidants. © 2017 Elsevier B.V.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6