Design of microparticles containing natural antioxidants: Preparation, characterization and controlled release studies

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Joana Aguiar (Author) FEUP; Raquel Costa (Author) FEUP; F. Rocha (Author) FEUP; B. N. Estevinho (Author) FEUP; L. Santos (Author) FEUP

Journal

Title: Powder Technology

Vol. 313

Pages: 287-292

ISSN: 0032-5910

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 10 Citations

ISI Web of Science

Scopus - 31 Citations

INSPEC

Scientific classification

FOS: Engineering and technology

Associated Projects

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

LEPABE-2-ECO-INNOVATION - LEPABE-2-ECO-INNOVATION

Other information

Authenticus ID: P-00M-H7V

DOI: 10.1016/j.powtec.2017.03.013

Abstract (EN): Antioxidants are important compounds in the prevention of diseases like cancer, diabetes, cardiovascular, neurodegenerative diseases and premature aging, however they are very sensitive to the light, heat, oxygen and pH. In this study, caffeic acid (CAF), chlorogenic acid (CGA) and rosmarinic acid (RA), 3 natural antioxidants, were encapsulated by spray-drying using sodium carboxymethyl cellulose (Na-CMC) to overcome their limitations in industrial applications. Product yield values were around 40% and the encapsulation efficiency values were higher than 90%. Particles revealed a smooth spherical shape with mean diameter below 11 ¿m (considering volume size distribution). Microparticles loaded with CAF, CGA and RA were fully released after 45 min, 2 h and 4 h, respectively. Antioxidant activity was not compromised, highlighting the potential of spray-dried Na-CMC microparticles as carriers of natural antioxidants. © 2017 Elsevier B.V.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6