Genetic Epidemiology

Code:

MSP12_18

Acronym:

MSP12_18

Keywords
Classification	Keyword
OFICIAL	Epidemiology

Instance: 2021/2022 - 2S (of 07-02-2022 to 15-07-2022)

Active?	Yes
Responsible unit:	Public Health and Forensic Sciences, and Medical Education Department
Course/CS Responsible:	Master Degree Course in Public Health

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MSP	0	Current Studies Plan	1	-	3	27	81

Teaching language

English

Objectives

Acquisition of knowledge on the fundamental concepts and specific methods of genetic epidemiology. We aim that the students: (i) recognize the importance of Genetic Epidemiology in Medicine and in the Biomedical Research and (ii) are able to interpret a Genetic Epidemiology study from the evaluation of the genetic component to the identification of the genetic factors responsible for that disease.

Learning outcomes and competences

The students should be able to interpret the pedigrees and to recognize the different inheritance patterns of a disease and to estimate the risk for the other relatives. They should have also acquired the knowledge to evaluate familial aggregation of a disease. Also, the students should be able to use the appropriated methodologies to map genes in the genome and to perform association studies. Also the students will be able to estimate allelic and genotypic frequencies in a population. Ultimately, they will able to perform a critical review of a Genetic Epidemiology study and to design an experimental study.

Working method

B-learning

Program

Introduction to Genetic Epidemiology. Fundamental concepts of Genetics. Mendelian inheritance modes. Familial aggregation of a disease. Basic concepts of Population Genetics: Hardy-Weinberg equilibrium. Linkage analysis. Gene mapping in mendelian diseases. Complex diseases: non-parametric linkage and association studies.

Mandatory literature

Vogel F; Human genetics. ISBN: 3-540-60290-9
King Richard A. ed; Genetic Basis of Common Diseases. ISBN: 0-19-512582-7
Khoury, Beaty, Cohen; Fundamentals of Genetic Epidemiology. ISBN: -10: 0195052889

Complementary Bibliography

Strachan & Read; Human Molecular Genetics 4. ISBN: 9780815341499

Comments from the literature

Bibliography will also include scientific papers with relevance to the topics under study

Teaching methods and learning activities

A total of 81 hours of student’s work, of which 27 are of contact, distributed as follows is estimated: T:15 and TP:12.

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Designation	Weight (%)
Defesa pública de dissertação, de relatório de projeto ou estágio, ou de tese	60,00
Trabalho escrito	40,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Elaboração de relatório/dissertação/tese	40,00
Estudo autónomo	14,00
Frequência das aulas	27,00
Total:	81,00

Eligibility for exams

 To be present in at least 75% of the classes.

Calculation formula of final grade

Students will have to make a critical analysis of a scientific paper, through a written report with oral presentation.

Criteria weighting of each of the evaluation components of the final grade of the course: written report (40%); oral presentation (60%).