Project: COMPETE2030-FEDER-00730700- DESIPOP

Project name:	DESIPOP - DESIPOP - Multifunctional polymer meta-biomaterial implants, for prolapse repair, by design
Project code:	COMPETE2030-FEDER-00730700- DESIPOP
Intervention Region:	Norte
Proposing institution/Lead promoter/Coordinating entity:	Instituto de Ciência e Inovação em Engenharia Mecânica e Engenharia Industrial
Partner(s)/Co-promoter(s)/Participating institution(s):	Faculdade de Medicina da Universidade do Porto
Start date:	2025-01-02
Completion date:	2027-12-31

Objectives, activities and expected/achieved results

The GOAL OF THIS PROJECT is the development of novel multifunctional polymer meta-biomaterial implants for women's prolapse reconstructive surgery.
The MAIN SPECIFIC OBJECTIVES are:
1.SO1: Explore and optimize novel auxetic mesh implant structures designed, for enhanced functionality, and evaluate their deformation mechanism and mechanical properties by fi nite element modelling and simulation studies
2.SO2: Fabricate, by additive manufacturing ( melt electrospinning and/or FDM ) novel biodegradable multifunctional implant meshes with auxeticity and drug release capabilities, ready for in vitro testing, based on quantitative and qualitative parameters, namely meta-biomaterial chemical composition, constitutive equations parameters, geometry patterns; mechanical properties; 3.SO3 : Develop predictive models of implant degradation and methods for accurate prediction of degradation profi les in vitro
4.SO4: Evaluate functional characteristics beyond biocompatibility, such as biodegradability, auxeticity and drug release, without affecting their intrinsic properties or adversely affecting the host response.
5.SO5 : Study in vitro and in vivo the release kinetics of the drug release and its effect on the growth/proliferation and adhesion of bacteria and its rate of clearance/inhibition, to optimize antibiotic/anti-infl ammatory selection.

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