Project: HORIZON-CL4-2022-RESILIENCE-01

Project name:	REBORN - Remodelling of the infarcted heart: piezoelectric multifunctional patch enabling the sequential release of therapeutic factors
Project code:	HORIZON-CL4-2022-RESILIENCE-01
Proposing institution/Lead promoter/Coordinating entity:	Politecnico di Torino
Partner(s)/Co-promoter(s)/Participating institution(s):	BEWARRANT; BIOINICIA SL; CELLOGIC GMBH; CORCYM S.R.L.; Faculdade de Medicina da Universidade de Coimbra; Faculdade de Medicina da Universidade do Porto; Instituto de Investigação e Inovação em Saúde da Universidade do Porto; La Scuola Superiore di Studi Universitari e Perfezionamento Sant'Anna; REGEMAT 3D LTD
Start date:	2023-01-01
Completion date:	2026-12-31

Objectives, activities and expected/achieved results

Main objective: development of an acellular, piezoelectric patch enabling on demand, sequential release of anti-inflammatory, anti-fibrotic and CM proliferative factors as well as electromechanical coupling with the myocardium to promote functional heart remodelling whilst reducing arrhythmogenic risks.

UP: definition of clinical requirements and specifications, ethical approval and execution of in vivo test in large animals, definition of minimally invasive procedure for the cardiac patch application.

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