Apresentação Pessoal

Patricia Monteiro is a Principal Investigator at the Faculty of Medicine of the University of Porto (FMUP), Portugal.
She holds a BSc/MSc degree in Pharmaceutical Sciences and a PhD degree in Neuroscience.

Dr. Monteiro did her Ph.D. training with Prof. Guoping Feng at the Massachusetts Institute of Technology (MIT, USA), where she focused on understanding brain circuitry mechanisms underlying repetitive behaviors present in obsessive-compulsive (OCD) and autism-spectrum disorders (ASD). She published a study showing reversal of autistic-like behaviors in adult mice by restoring the Shank3 gene [Nature, 2016] and coauthored another publication showing that particular human mutations in the Shank3 gene can lead to distinct neuropsychiatric disorders [Neuron, 2016]. Before starting her own lab, she worked with Prof. Nuno Sousa at ICVS University of Minho, studying the impact of chronic stress on brain circuits under an EMBO postdoctoral fellowship.

Dr. Monteiro's lab uses electrophysiology brain recordings together with novel neuroengineering approaches to study neuropsychiatric and neurodevelopmental disorders.
She is an invited junior member of the Portuguese National Academy of Sciences and an Advisory Board Member of the European Molecular Biology Organization (EMBO), serving for their Scientific Exchange Grants (SEG) program.

 
Lab website:
https://www.neuro-ephys.org/

On the news:

- Patricia Monteiro - The Branco Weiss Fellowship - Society in Science
- Foi possível reverter sintomas do autismo em ratinhos adultos | Neurociências | PÚBLICO
- Making and Breaking Compulsive Behaviour (nationalgeographic.com)
- Investigadores da FMUP criam dispositivo para combater doencas neurologicas

Selected publications:

Rodrigues D, Santa C, Manadas B, Monteiro P.
Chronic Stress Alters Synaptic Inhibition/Excitation Balance of Pyramidal Neurons But Not PV Interneurons in the Infralimbic and Prelimbic Cortices of C57BL/6J Mice.
eNeuro. Aug 27;11(8):ENEURO.0053-24.2024. (2024).

Reis S, Monteiro P.
From synaptic dysfunction to atypical emotional processing in autism.
FEBS Lett. Feb;598(3):269-282. (2024).

Santa C*, Rodrigues D*, Coelho JF, Anjo SI, Mendes VM, Bessa-Neto D, Dunn MJ, Cotter D, Baltazar G, , Monteiro P* and Manadas B*.
Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons.
*shared first and senior authorship.
Transl Psychiatry. Oct 6;13(1):312. (2023).

Goncalves AM, Sousa N, Jacinto L, Monteiro P.
The Shank3-InsG3680(+/+) mouse model of autism spectrum disorder displays auditory avoidance in a novel behavioral test.
Front. Behav. Neurosci. Aug 24;17:1205507. (2023).

Rodrigues D, Jacinto L, Falcao M, Castro CA, Cruz A, Santa C, Manadas B, Marques F, Sousa N, Monteiro P.
Chronic stress causes striatal disinhibition mediated by SOM-interneurons.
Nat.Commun. 13, 7355. (2022).

Castro AC and Monteiro P. 
Auditory Dysfunction in Animal Models of Autism Spectrum Disorder. 
Front Mol Neurosci. 15:845155. (2022).

Machado F, Sousa N, Monteiro P* and Jacinto L*.
A versatile and modular tetrode-based device for single-unit recordings in rodent ex vivo and in vivo acute preparations. 
J Neurosci Methods 108755. (2020). 

Monteiro P., Barak B, Zhou Y, McRae R, Rodrigues D, Wickersham IR, and Feng G.
Dichotomous parvalbumin interneuron populations in dorsolateral and dorsomedial striatum.
The Journal of Physiology 596: 3695-3707. (2018).

Monteiro P. and Feng G.
SHANK proteins: roles at the synapse and in autism spectrum disorder.
Nature Reviews Neuroscience 18(3):147-157. (2017).

Mei Y*, Monteiro P*, Zhou Y, Kim J, Gao X, Fu Z, and Feng G.
Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. *These authors contributed equally to this work.
Nature 530(7591):481-4. (2016). 

Zhou Y, Kaiser T*, Monteiro P*, Zhang X*,  Van der Goes MS, Wang D, Barak B, Zeng M, LiC, Lu C, Wells M, Amaya A, Nguyen S, Lewis M, Sanjana N, Zhou Y, Zhang M, Zhang F, Fu Z, Feng G.
Mice with Shank3 mutations associated with ASD and schizophrenia display both shared and distinct defects. *These authors contributed equally to this work.
Neuron 89:147-162. (2016). 

Kaiser T*, Ting J*, Monteiro P and Feng G.
Transgenic labeling of parvalbumin-expressing neurons with tdTomato.
Neuroscience 3;321:236-45. (2015). 

Burguière E, Monteiro P, Feng G and Graybiel AM.
Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors. 
Science 340(6137):1243-6. (2013).