Antibiotic resistance of mixed biofilms in cystic fibrosis: impact of emerging microorganisms on treatment of infection

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Susana Patrícia Lopes (Autor) Outra; Howard Ceri (Autor) Outra; Nuno Filipe Azevedo (Autor) FEUP; Maria Olívia Pereira (Autor) Outra

Revista

Título: International Journal of Antimicrobial Agents

Vol. 40 Nº 3

Páginas: 260-263

ISSN: 0924-8579

Editora: Elsevier

Indexação

ISI Web of Knowledge - 49 Citações

Scopus - 64 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Ciências da saúde

Projetos Associados

PEst-C/EQB/UI0511/2011 - PROJECTO ESTRATÉGICO - UI 511 - 2011-2012

Outras Informações

ID Authenticus: P-002-6FY

DOI: 10.1016/j.ijantimicag.2012.04.020

Abstract (EN): Cystic fibrosis (CF) is a genetic disorder associated with multispecies infections where interactions between classical and newly identified bacteria might be crucial to understanding the persistent colonisation in CF lungs. This study investigated the interactions between two emerging species, Inquilinus limosus and Dolosigranulum pigrum, and the conventional CF pathogen Pseudomonas aeruginosa by evaluating the ability to develop biofilms of mixed populations and then studying their susceptibility patterns to eight different antimicrobials. Monospecies biofilms formed by I. limosus and D. pigrum produced significantly less biomass than P. aeruginosa and displayed greater sensitivity to antimicrobials. However, when in dual-species biofilms with P. aeruginosa, the emerging species I. limosus and D. pigrum were crucial in increasing tolerance of the overall consortia to most antibiotics, even without a change in the number of biofilm-encased cells. These results may suggest that revising these and other species interactions in CF might enable the development of more suitable and effective therapies in the future.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4