Diarylpentanoids with antitumor activity: A critical review of structure-activity relationship studies

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Moreira, J (Autor) Outra; Lucilia Saraiva (Autor) FFUP; Pinto, MM (Autor) Outra; Honorina Cidade (Autor) FFUP

Revista

Título: European Journal of Medicinal Chemistry

Vol. 192

ISSN: 0223-5234

Editora: Elsevier

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 13 Citações

Outras Informações

ID Authenticus: P-00R-VCG

DOI: 10.1016/j.ejmech.2020.112177

Abstract (EN): Diarypentanoids are commonly considered as monocarbonyl analogues of curcumin. Since the discovery of this compound in 1962, twenty one diarylpentanoids have been isolated and almost 600 synthetic analogues with antitumor activity have been synthesized. This review reports the exploitation of diarylpentanoids to develop curcumin analogues with improved antitumor activity over the last two decades. The mechanism of action and structure-activity relationship (SAR) studies are also highlighted. More importantly, structural features for the antitumor activity that may guide the design of new and more effective diarylpentanoids are also proposed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 26