Evaluation of nickel toxicity on liver, spleen, and kidney of mice after administration of high-dose metal ion

• Tipo: Artigo em Revista Científica Internacional
• Data: 1998

Autores

Pereira, MC (Autor) Outra; Pereira, ML (Autor) Outra; Sousa, JP (Autor) Outra

Revista

Título: Journal of Biomedical Materials Research

Vol. 40

Páginas: 40-47

ISSN: 0021-9304

Editora: Heterocorporation

Indexação

ISI Web of Knowledge - 39 Citações

Scopus - 40 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Biotecnologia ambiental

Outras Informações

ID Authenticus: P-001-86P

DOI: 10.1002/(sici)1097-4636(199804)40:1<40::aid-jbm5>3.0.co;2-r

Abstract (EN): The toxic effects caused by nickel (Ni) per si were explored by performing in vivo studies on mice following subcutaneous administration of a metallic solution of nickel at 1, 2, 3, and 4 weeks to evaluate the side effects of this metal ion when released from stainless steel implants. Other groups were similarly injected with HBSS and used as controls. Accumulation of Ni ions on liver, spleen, and kidney was assessed by an electrochemical method, adsorptive stripping voltammetry (AdSV) using microelectrodes, and atomic absorption spectrometry (AAS). Alterations of those organs induced by Ni ions were studied, showing that several histological changes had been induced. Chemical analysis and histological features indicate that Ni is partially accumulated in the study organs. (C) 1998 John Wiley & Sons, Inc.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8