Redox imbalance in age-related ovarian dysfunction and perspectives for its prevention

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Timoteo Ferreira, F (Autor) Outra; Abreu, D (Autor) Outra; Mendes, S (Autor) Outra; Matos, Liliana (Autor) FCNAUP; Rodrigues, AR (Autor) Outra; Almeida, H (Autor) Outra; Silva, E (Autor) Outra

Revista

Título: Ageing Research Reviews

Vol. 68

ISSN: 1568-1637

Editora: Elsevier

Indexação

ISI Web of Knowledge - 8 Citações

Scopus - 9 Citações

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-00T-Z50

DOI: 10.1016/j.arr.2021.101345

Abstract (EN): The age at which women have their first child is increasing. This change represents a major health problem to society because advanced maternal age is related with a decay in fertility and an increase in the incidence of a variety of pregnancy complications and offspring health issues. The ovary stands as the main contributor for female reproductive ageing because of the progressive age-related decrease in follicle number and oocyte quality. Loss of redox homeostasis and establishment of an ovarian oxidative microenvironment are seen as major underlying causes for such downfall and impairment of ovarian function. Thus, the use of antioxidants to preserve fertility became an important field of research. In this review, new insights on mechanisms underlying the establishment of oxidative stress and its repercussions on ovarian ageing are addressed, along with the current state of knowledge on antioxidant supplementation and its contribution for healthy ageing and extension of ovarian lifespan.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10