Xanthone derivatives: New insights in biological activities

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2005

Autores

Pinto, MMM (Autor) FFUP; Sousa, ME (Autor) FFUP; Nascimento, MSJ (Autor) FFUP

Revista

Título: Current Medicinal Chemistry

Vol. 12

Páginas: 2517-2538

ISSN: 0929-8673

Editora: Bentham Science

Indexação

ISI Proceedings

ISI Web of Knowledge - 408 Citações

Scopus - 419 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-000-5GM

DOI: 10.2174/092986705774370691

Abstract (EN): Xanthones or 9H-xanthen-9-ones (dibenzo-y-pirone) comprise an important class of oxygenated heterocycles whose role is well-known in Medicinal Chemistry. The biological activities of this class of compounds are associated with their tricyclic scaffold but vary depending on the nature and/or position of the different substituents. In this review, an array of biological/pharmacological effects is presented for both natural and synthetic xanthone derivatives, with an emphasis on some significant studies on structure-activity relationships. The antitumor activity of some xanthones as well as the related targets, particularly PKC modulation studies, is also discussed in detail. Examples of the "hit" compounds involved in cancer therapy, namely DMXAA, psorospermin, mangiferin, norathyriol, mangostins, and AH6809, a prostanoid receptor antagonist, are also mentioned. Finally, a historical perspective of these xanthonic derivatives, their relevance as therapeutic agents and/or their uses as pharmacological tools and as extract components in folk medicine are also highlighted.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 22