Discovery of MAO-B Inhibitors - Present Status and Future Directions Part I: Oxygen Heterocycles and Analogs

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Helguera, AM (Autor) Outra; Perez Machado, G (Autor) Outra; Cordeiro, MNDS (Autor) FCUP; Borges, F (Autor) FCUP

Revista

Título: Mini-Reviews in Medicinal Chemistry

Vol. 12

Páginas: 907-919

ISSN: 1389-5575

Editora: Bentham Science

Indexação

ISI Web of Knowledge - 36 Citações

Scopus - 41 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências Físicas > Química > Química aplicada > Química farmacêutica

Outras Informações

ID Authenticus: P-002-64Y

DOI: 10.2174/138955712802762301

Abstract (EN): Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The role of monoamine oxidase (MAO) inhibitors has expanded in the PD treatment. The present review will summarize the current structure-activity relationship information available on MAOs inhibitors of unrelated families of compounds of oxygen heterocyclic type based on coumarin, chromone and chalcone scaffolds. As the current hitting-one-target therapeutic strategy has been proved to be quite inefficient in PD, this review will also discuss about the development of multi-target drugs, in which MAO inhibition plays a counter-part, as a novel and promising treatment approach for PD.

Idioma: Inglês

Tipo (Avaliação Docente): Científica