Bacterial Cellulose: Long-Term Biocompatibility Studies

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Renata A N Pertile (Autor) Outra; Susana Moreira (Autor) Outra; Gil da Costa, R. M. (Autor) FEUP; Alexandra Correia (Autor) ICBAS; Luisa Guardao (Autor) Outra; Fatima Gartner (Autor) ICBAS; Manuel Vilanova (Autor) ICBAS; Miguel Gama (Autor) Outra

Revista

Título: Journal of Biomaterials Science, Polymer Edition

Vol. 23 Nº 10

Páginas: 1339-1354

ISSN: 0920-5063

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 100 Citações

Scopus - 109 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Biotecnologia ambiental

CORDIS: Ciências Tecnológicas > Engenharia

Outras Informações

ID Authenticus: P-002-FR1

DOI: 10.1163/092050611x581516

Abstract (EN): The bacterial cellulose (BC) secreted by Gluconacetobacter xylinus is a network of pure cellulose nanofibres which has high crystallinity, wettability and mechanical strength. These characteristics make BC an excellent material for tissue-engineering constructs, noteworthy for artificial vascular grafts. In this work, the in vivo biocompatibility of BC membranes produced by two G. xylinus strains was analyzed through histological analysis of long-term subcutaneous implants in the mice. The BC implants caused a mild and benign inflammatory reaction that decreased along time and did not elicit a foreign body reaction. A tendency to calcify over time, which may be related to the porosity of the BC implants, was observed, especially among the less porous BC-1 implants. In addition, the potential toxicity of BC nanofibres - obtained by chemical-mechanical treatment of BC membranes - subcutaneously implanted in mice was analysed through bone marrow flow cytometry and histological analyses. At 2 and 4 months post-implantation, the nanofibres implants were found to accumulate intracellularly, in subcutaneous foamy macrophages aggregates. Moreover, no differences were observed between the controls and implanted animals in thymocyte populations and in B lymphocyte precursors and myeloid cells in the bone marrow. (C) Koninklijke Brill NV, Leiden, 2011

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16