Systematic Review of the Incidence of and Risk Factors for Urothelial Cancers and Renal Cell Carcinoma Among Patients with Haematuria

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2022

Autores

Rai, BP (Autor) Outra; Escrig, JLD (Autor) Outra; Vale, L (Autor) FMUP; Kuusk, T (Autor) Outra; Capoun, O (Autor) Outra; Soukup, V (Autor) Outra; Bruins, HM (Autor) Outra; Yuan, YH (Autor) Outra; Violette, PD (Autor) Outra; Santesso, N (Autor) Outra; van Rhijn, BWG (Autor) Outra; Mostafid, AH (Autor) Outra; Omar, MI (Autor) Outra

Revista

Título: European Urology

Vol. 82

Páginas: 182-192

ISSN: 0302-2838

Editora: Elsevier

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 19 Citações

Outras Informações

ID Authenticus: P-00W-CRP

DOI: 10.1016/j.eururo.2022.03.027

Abstract (EN): Context: The current impact of haematuria investigations on health care organisations is significant. There is currently no consensus on how to investigate patients with haema-turia.Objective: To evaluate the incidence of bladder cancer, upper tract urothelial carcinoma (UTUC), and renal cell carcinoma (RCC) among patients undergoing investigation for haematuria and identify any risk factors for bladder cancer, UTUC, and RCC (BUR).Evidence acquisition: Medline, Embase, and Cochrane controlled trials databases and ClinicalTrials.gov were searched for all relevant publications from January 1, 2000 to June 2021 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Prospective, retrospective, and cross-sectional studies with a minimum population of 50 patients with haematuria were considered for the review.Evidence synthesis: A total of 44 studies were included. The total number of participants was 229 701. The pooled incidence rate for urothelial bladder cancer was 17% (95% con-fidence interval [CI] 14-20%) for visible haematuria (VH) and 3.3% (95% CI 2.45-4.3%) for nonvisible haematuria (NVH). The pooled incidence rate for RCC was 2% (95% CI 1-2%) for VH and 0.58% (95% CI 0.42-0.77%) for NVH. The pooled incidence rate for UTUC was 0.75% (95% CI 0.4-1.2%) for VH and 0.17% (95% CI 0.081-0.299%) for NVH. On sen-sitivity analysis, the proportions of males (risk ratio [RR] 1.14, 95% CI 1.10-1.17 for VH; 1.54, 95% CI 1.34-1.78 for NVH; p < 0.00001; moderate certainty evidence) and indi-viduals with a smoking history (RR 1.41, 95% CI 1.24-1.61 for VH; 1.53, 95% CI 1.36-1.72 for NVH; p < 0.00001; moderate certainty evidence) appeared to be higher in BUR than in non-BUR groups.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11