Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Sousa, A (Autor) Outra; Azevedo, R (Autor) Outra; Costa, VM (Autor) Outra; Oliveira, S (Autor) Outra; Preguica, I (Autor) Outra; Viana, S (Autor) Outra; Reis, F (Autor) Outra; Almeida, A (Autor) Outra; Matafome, P (Autor) Outra; Dias Pereira, P (Autor) Outra; Carvalho, F (Autor) Outra; Eduarda Fernandes (Autor) FFUP; Freitas, M (Autor) Outra

Revista

Título: Archives of Toxicology

Vol. 97

Páginas: 2643-2657

ISSN: 0340-5761

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Y-XPS

DOI: 10.1007/s00204-023-03558-5

Abstract (EN): Silver nanoparticles (AgNP) are among the most widely commercialized nanomaterials globally, with applications in medicine and the food industry. Consequently, the increased use of AgNP in the food industry has led to an unavoidable rise in human exposure to these nanoparticles. Their widespread use raises concerns about potential hazards to human health, specifically their intestinal pro-inflammatory effects. Thus, the main objective of this study was to evaluate the biological effects of two subacute doses of 5 nm polyvinylpyrrolidone (PVP)-AgNP in C57BL/6J mice. One mg/kg body weight or 10 mg/kg bw was provided once a day for 14 days, using a new technology (HaPILLness) that allows voluntary, stress-free, and accurate oral dosing. It was observed that after oral ingestion, while AgNP is biodistributed throughout the entire organism, most of the ingested dose is excreted in the feces. The passage and accumulation of AgNP throughout the intestine instigated a prominent inflammatory response, marked by significant histological, vascular, and cellular transformations. This response was driven by the activation of the nuclear factor-kB (NF-kB) inflammatory pathway, ultimately leading to the generation of multiple cytokines and chemokines.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15