Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Matos, A (Autor) Outra; Castelao, C (Autor) Outra; da Silva, AP (Autor) Outra; Alho, I (Autor) Outra; Bicho, M (Autor) Outra; Rui Medeiros (Autor) ICBAS; Bicho, MC (Autor) Outra

Revista

Título: Oxidative Medicine and Cellular Longevity

Vol. 2016

Páginas: 1-7

ISSN: 1942-0900

Editora: Hindawi

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 12 Citações

Outras Informações

ID Authenticus: P-00K-3RA

DOI: 10.1155/2016/2769804

Abstract (EN): There is a clear association between the excessive and cumulative exposure to estrogens and the development of cancer in hormone-sensitive tissues, such as the cervix. We studied the association of CYP1A1 M1 (rs4646903) and COMT (rs4680) polymorphisms in 130 cervical cancer cases (c-cancer) and 179 controls. The CYP1A1 TT genotype was associated with a lower risk for c-cancer (OR = 0.39, p = 0.002). The allele C of CYP1A1 was a risk for c-cancer (OR = 2.29, p = 0.002). Women with COMT LL genotype had a higher risk of developing c-cancer (OR = 4.83, p < 0.001). For the interaction of the CYP1A1&COMT, we observed that TC&HL genotypes had a greater risk for c-cancer (OR = 6.07, p = 0.006) and TT&HL genotypes had a protection effect (OR = 0.24, p < 0.001). The CYP1A1 TT and COMT LL genotypes had higher estradiol levels in c-cancer (p < 0.001 and p = 0.037, resp.). C-cancer is associated with less production of 2-methoxy-estradiol resultant of functional polymorphisms of CYP1A1 and COMT, separately. CYP1A1 and COMT work in a metabolic sequence and their interaction could lead to an alternative pathway of estrogen metabolism with production of 16-OH-estrone that is more proliferative.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7