Hyaluronic acid-conjugated pH-sensitive liposomes for targeted delivery of prednisolone on rheumatoid arthritis therapy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Gouveia, VM (Autor) Outra; Lopes de Araujo, J (Autor) Outra; Costa Lima, SAC (Autor) Outra; Nunes, C (Autor) Outra; Salette Reis (Autor) FFUP

Revista

Título: Nanomedicine

Vol. 13

Páginas: 1037-1049

ISSN: 1743-5889

Editora: Future Medicine Ltd.

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 19 Citações

Outras Informações

ID Authenticus: P-00Q-E80

DOI: 10.2217/nnm-2017-0377

Abstract (EN): Aim: The treatment of rheumatoid arthritis remains a challenge as available therapies still entail the risk of deleterious off-target effects. The present study describes hyaluronic acid-conjugated pH-sensitive liposomes as an effective drug delivery-targeting strategy to synovial cells. Materials & methods: Therapeutic, cytotoxic and targeting potential of developed liposomes were studied in vitro using macrophages and fibroblasts cell lines. Results & Conclusion: Results suggest an enhanced cellular uptake of conjugated liposomes, mainly mediated by caveolae- and clathrin-dependent endocytosis. In vitro release studies demonstrated that prednisolone was preferentially released under acidic conditions mimicking intracellular endosomal compartments. Overall, results revealed that conjugated pH-sensitive liposomes are a promising nanoapproach for the targeted delivery of prednisolone within inflamed synovial cells for rheumatoid arthritis treatment.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13