Obesity, energy balance and spermatogenesis

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2017

Autores

Oliveira, PF (Autor) FMUP; sousa, m (Autor) ICBAS; Sliva, BM (Autor) Outra; Monteiro, M (Autor) ICBAS; Alves, MG (Autor) Outra

Revista

Título: Reproduction

Vol. 153

Páginas: R173-R185

ISSN: 1470-1626

Editora: BioScientifica Ltd.

Indexação

ISI Web of Knowledge - 19 Citações

Scopus - 41 Citações

Outras Informações

ID Authenticus: P-00M-V55

DOI: 10.1530/rep-17-0018

Abstract (EN): Obesity has grown to pandemic proportions. It affects an increasing number of children, adolescents and young adults exposed to the silent comorbidities of this disorder for a longer period. Infertility has arisen as one important comorbidity associated with the energy dysfunction promoted by obesity. Spermatogenesis is a highly regulated process that is determined by specific energetic requirements. The reproductive potential of males relies on hormonal-dependent and - independent stimuli that control sperm quality. There are conflicting data concerning the impact of male overweight and obesity on sperm quality, as well as on the possible paternal-induced epigenetic trait inheritance of obesity. In addition, it remains a matter of debate whether massive weight loss induced by lifestyle interventions, drugs or bariatric surgery may or may not benefit obese men seeking fatherhood. Herein, we propose to discuss how energy balance may modulate hormonal signalling and sperm quality in overweight and obese men. We also discuss some molecular mechanisms that mediate obesity-related dysfunction in male reproductive system and how paternal obesity may lead to trait inheritance. Finally, we will discuss how lifestyle modifications and sustained weight loss, particularly the loss achieved by bariatric surgery, may revert some of the deleterious effects of obesity in men and their offspring.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13